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DATE: 31 March 2020

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ABSTRACT:

SIRT1 inhibitors can reduce replication of many viruses with certain similar characteristics to those of Coronaviruses, while p53 protein is another important factor in down-regulation of growth. There are some molecules that inhibit Sirtuin 1 and 2, in addition to activate p53 protein, by means of regulation of the interactions used by Coronaviruses as self-defense mechanism, degradating it. Even mTOR signal will be regulate, as well as HIF-1α with the target genes and cytokines. Autophagy will be inhibited, being this compound like a lysosomotropic agent. By blocking virus growth and continuous replication, associating the already tested Antiviral medicines, Covid-19 could be eradicated.

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Keywords: 
Coronavirus, Covid-19, Covid, Sars-Cov-2, Coronavirus replication, SIRT1 inhibitors, SIRT1, p53 mTOR, Autophagy 

Lysosomotropic, HIF-1α, HIF, Cytokines, Cytokines Storm

 

License (for files):

Creative Commons Attribution 4.0 International

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CITATION:

APA

Smith, K., Dr. (2020, August 5). Eradicate Coronavirus by blocking replication, counteracting its defense system.

 

MLA

Smith, Kira, Dr. “Eradicate Coronavirus by Blocking Replication, Counteracting Its Defense System.” OSF Preprints, 5 Aug. 2020. Web.

 

Chicago

Smith, Kira, Dr. 2020. “Eradicate Coronavirus by Blocking Replication, Counteracting Its Defense System.” OSF Preprints. August 5. doi:10.31219/osf.io/psz35.