Research
eradicate coronavirus by blocking replication, counteracting its defense system
DATE: 31 March 2020
ABSTRACT:
SIRT1 inhibitors can reduce replication of many viruses with certain similar characteristics to those of Coronaviruses, while p53 protein is another important factor in down-regulation of growth. There are some molecules that inhibit Sirtuin 1 and 2, in addition to activate p53 protein, by means of regulation of the interactions used by Coronaviruses as self-defense mechanism, degradating it. Even mTOR signal will be regulate, as well as HIF-1α with the target genes and cytokines. Autophagy will be inhibited, being this compound like a lysosomotropic agent. By blocking virus growth and continuous replication, associating the already tested Antiviral medicines, Covid-19 could be eradicated.
Keywords:
Coronavirus, Covid-19, Covid, Sars-Cov-2, Coronavirus replication, SIRT1 inhibitors, SIRT1, p53 mTOR, Autophagy
Lysosomotropic, HIF-1α, HIF, Cytokines, Cytokines Storm
License (for files):
Creative Commons Attribution 4.0 International
CITATION:
APA
Smith, K., Dr. (2020, August 5). Eradicate Coronavirus by blocking replication, counteracting its defense system.
MLA
Smith, Kira, Dr. “Eradicate Coronavirus by Blocking Replication, Counteracting Its Defense System.” OSF Preprints, 5 Aug. 2020. Web.
Chicago
Smith, Kira, Dr. 2020. “Eradicate Coronavirus by Blocking Replication, Counteracting Its Defense System.” OSF Preprints. August 5. doi:10.31219/osf.io/psz35.
Do you have any scientific material that you would like to see published, but don't know who to address to?
Send us your articles, we will evaluate them!